On November 4, George Gagnidze makes his Atlanta Opera debut with his signature role of Rigoletto. George reprises Tomer Zvulun's staging he performed in to great acclaim last year at the Dallas Opera ("Mr. Gagnidze is a dream singer for any opera house.“ EarRelevant), with Roberto Kalb leading the Atlanta Opera Orchestra and Chorus. Won Whi Choi is the Duke of Mantua, Jasmine Habersham Gilda, David Crawford Monterone, Patrick Guetti Sparafucile and Olivia Vote Maddelena. There are additional shows taking place on November 7, 10 and 12, with the November 10 performance being live video streamed on the Atlanta Opera website.

George Gagnidze is set to perform his first Nabucco at the Metropolitan Opera. The revival of Elijah Moshinsky's striking staging is conducted by Paolo Carignani and sees George sing the role of the Babylonian king in 13 performances alongside Liudmyla Monastyrska as Abigaille, Maria Barakova as Fenena, SeokJong Baek and Rafael Davila as Ismaele as well as Dmitry Belosselskiy as Zaccaria.

After three performances earlier in the season, on April 27, 2023, George Gagnidze returns to the role of Amonasro in Aida at the Metropolitan Opera for six additional shows, in the Sonya Frisell production and under the musical direction of Paolo Carignani.

On March 17, 2023, George Gagnidze returns to the Hamburg State Opera as the protagonist of Rigoletto on the occasion of the theatre's "Italian Opera Weeks". In the production by Andreas Homoki George appears under the musical direction of Stefano Ranzani and alongside Pretty Yende as Gilda, Matthew Polenzani as Duca di Mantova, Tigran Martirossian as Sparafucile and Marta Swiderska as Maddalena. There are two additional performances on March 22 and 25.

A brand new role for George Gagnidze, who makes his debut as the High Priest of Dagon (Grand-Prêtre de Dagon) in Samson et Dalila at the Staatsoper Unter den Linden in Berlin on February 12, 2023, in a production by Damian Szifron led by Thomas Guggeis. He will sing alongside Brian Jagde as Samson, Elīna Garanča as Dalila, and Grigory Shkarupa as Abimelech. There will be two additional performances on February 15 and 18.